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Huntington F. Willard, PhD

Publications

Horvath JE, Willard HF.
Primate comparative genomics: lemur biology and evolution.
Trends Genet. 2007 Apr;23(4):173-82. Epub 2007 Feb 27. Review.
PMID: 17331617 [PubMed - indexed for MEDLINE]

Haga SB, Willard HF.
Defining the spectrum of genome policy.
Nat Rev Genet. 2006 Dec;7(12):966-72. Review.
PMID: 17139328 [PubMed - indexed for MEDLINE]

Shianna KV, Willard HF.
Human genomics: in search of normality.
Nature. 2006 Nov 23;444(7118):428-9. No abstract available.
PMID: 17122840 [PubMed - indexed for MEDLINE]

Basu J, Willard HF.
Human artificial chromosomes: potential applications and clinical considerations.
Pediatr Clin North Am. 2006 Oct;53(5):843-53, viii. Review.
PMID: 17027613 [PubMed - indexed for MEDLINE]

Wang Z, Willard HF, Mukherjee S, Furey TS.
Evidence of influence of genomic DNA sequence on human X chromosome inactivation.
PLoS Comput Biol. 2006 Sep 1;2(9):e113. Epub 2006 Jul 17.
PMID: 16948528 [PubMed - indexed for MEDLINE]

Amos-Landgraf JM, Cottle A, Plenge RM, Friez M, Schwartz CE, Longshore J, Willard HF.
X chromosome-inactivation patterns of 1,005 phenotypically unaffected females.
Am J Hum Genet. 2006 Sep;79(3):493-9. Epub 2006 Jul 27.
PMID: 16909387 [PubMed - indexed for MEDLINE]

Valley CM, Pertz LM, Balakumaran BS, Willard HF.
Chromosome-wide, allele-specific analysis of the histone code on the human X chromosome.
Hum Mol Genet. 2006 Aug 1;15(15):2335-47. Epub 2006 Jun 20.
PMID: 16787966 [PubMed - indexed for MEDLINE]

Valley CM, Willard HF.
Genomic and epigenomic approaches to the study of X chromosome inactivation.
Curr Opin Genet Dev. 2006 Jun;16(3):240-5. Epub 2006 May 2. Review.
PMID: 16647845 [PubMed - indexed for MEDLINE]

Chadwick LH, Pertz LM, Broman KW, Bartolomei MS, Willard HF.
Genetic control of X chromosome inactivation in mice: definition of the Xce candidate interval.
Genetics. 2006 Aug;173(4):2103-10. Epub 2006 Apr 2.
PMID: 16582439 [PubMed - indexed for MEDLINE]

Scott KC, Merrett SL, Willard HF.
A heterochromatin barrier partitions the fission yeast centromere into discrete chromatin domains.
Curr Biol. 2006 Jan 24;16(2):119-29.
PMID: 16431364 [PubMed - indexed for MEDLINE]

Rudd MK, Wray GA, Willard HF.
The evolutionary dynamics of alpha-satellite.
Genome Res. 2006 Jan;16(1):88-96. Epub 2005 Dec 12.
PMID: 16344556 [PubMed - indexed for MEDLINE]

Higgins AW, Gustashaw KM, Willard HF.
Engineered human dicentric chromosomes show centromere plasticity.
Chromosome Res. 2005;13(8):745-62. Epub 2005 Dec 8.
PMID: 16331407 [PubMed - indexed for MEDLINE]

Chadwick LH, Willard HF.
Genetic and parent-of-origin influences on X chromosome choice in Xce heterozygous mice.
Mamm Genome. 2005 Sep;16(9):691-9. Epub 2005 Oct 20.
PMID: 16245026 [PubMed - indexed for MEDLINE]

Willard HF, Angrist M, Ginsburg GS.
Genomic medicine: genetic variation and its impact on the future of health care.
Philos Trans R Soc Lond B Biol Sci. 2005 Aug 29;360(1460):1543-50. Review.
PMID: 16096102 [PubMed - indexed for MEDLINE]

Schueler MG, Dunn JM, Bird CP, Ross MT, Viggiano L; NISC Comparative Sequencing Program, Rocchi M, Willard HF, Green ED.
Progressive proximal expansion of the primate X chromosome centromere.
Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10563-8. Epub 2005 Jul 19.
PMID: 16030148 [PubMed - indexed for MEDLINE]

Basu J, Compitello G, Stromberg G, Willard HF, Van Bokkelen G.
Efficient assembly of de novo human artificial chromosomes from large genomic loci.
BMC Biotechnol. 2005 Jul 5;5:21.
PMID: 15998466 [PubMed - indexed for MEDLINE]

Basu J, Willard HF.
Artificial and engineered chromosomes: non-integrating vectors for gene therapy.
Trends Mol Med. 2005 May;11(5):251-8. Review.
PMID: 15882613 [PubMed - indexed for MEDLINE]

Carrel L, Willard HF.
X-inactivation profile reveals extensive variability in X-linked gene expression in females.
Nature. 2005 Mar 17;434(7031):400-4.
PMID: 15772666 [PubMed - indexed for MEDLINE]

Ross MT, Grafham DV, Coffey AJ, Scherer S, McLay K, Muzny D, Platzer M, Howell GR, Burrows C, Bird CP, Frankish A, Lovell FL, Howe KL, Ashurst JL, Fulton RS, Sudbrak R, Wen G, Jones MC, Hurles ME, Andrews TD, Scott CE, Searle S, Ramser J, Whittaker A, Deadman R, Carter NP, Hunt SE, Chen R, Cree A, Gunaratne P, Havlak P, Hodgson A, Metzker ML, Richards S, Scott G, Steffen D, Sodergren E, Wheeler DA, Worley KC, Ainscough R, Ambrose KD, Ansari-Lari MA, Aradhya S, Ashwell RI, Babbage AK, Bagguley CL, Ballabio A, Banerjee R, Barker GE, Barlow KF, Barrett IP, Bates KN, Beare DM, Beasley H, Beasley O, Beck A, Bethel G, Blechschmidt K, Brady N, Bray-Allen S, Bridgeman AM, Brown AJ, Brown MJ, Bonnin D, Bruford EA, Buhay C, Burch P, Burford D, Burgess J, Burrill W, Burton J, Bye JM, Carder C, Carrel L, Chako J, Chapman JC, Chavez D, Chen E, Chen G, Chen Y, Chen Z, Chinault C, Ciccodicola A, Clark SY, Clarke G, Clee CM, Clegg S, Clerc-Blankenburg K, Clifford K, Cobley V, Cole CG, Conquer JS, Corby N, Connor RE, David R, Davies J, Davis C, Davis J, Delgado O, Deshazo D, Dhami P, Ding Y, Dinh H, Dodsworth S, Draper H, Dugan-Rocha S, Dunham A, Dunn M, Durbin KJ, Dutta I, Eades T, Ellwood M, Emery-Cohen A, Errington H, Evans KL, Faulkner L, Francis F, Frankland J, Fraser AE, Galgoczy P, Gilbert J, Gill R, Glockner G, Gregory SG, Gribble S, Griffiths C, Grocock R, Gu Y, Gwilliam R, Hamilton C, Hart EA, Hawes A, Heath PD, Heitmann K, Hennig S, Hernandez J, Hinzmann B, Ho S, Hoffs M, Howden PJ, Huckle EJ, Hume J, Hunt PJ, Hunt AR, Isherwood J, Jacob L, Johnson D, Jones S, de Jong PJ, Joseph SS, Keenan S, Kelly S, Kershaw JK, Khan Z, Kioschis P, Klages S, Knights AJ, Kosiura A, Kovar-Smith C, Laird GK, Langford C, Lawlor S, Leversha M, Lewis L, Liu W, Lloyd C, Lloyd DM, Loulseged H, Loveland JE, Lovell JD, Lozado R, Lu J, Lyne R, Ma J, Maheshwari M, Matthews LH, McDowall J, McLaren S, McMurray A, Meidl P, Meitinger T, Milne S, Miner G, Mistry SL, Morgan M, Morris S, Muller I, Mullikin JC, Nguyen N, Nordsiek G, Nyakatura G, O'Dell CN, Okwuonu G, Palmer S, Pandian R, Parker D, Parrish J, Pasternak S, Patel D, Pearce AV, Pearson DM, Pelan SE, Perez L, Porter KM, Ramsey Y, Reichwald K, Rhodes S, Ridler KA, Schlessinger D, Schueler MG, Sehra HK, Shaw-Smith C, Shen H, Sheridan EM, Shownkeen R, Skuce CD, Smith ML, Sotheran EC, Steingruber HE, Steward CA, Storey R, Swann RM, Swarbreck D, Tabor PE, Taudien S, Taylor T, Teague B, Thomas K, Thorpe A, Timms K, Tracey A, Trevanion S, Tromans AC, d'Urso M, Verduzco D, Villasana D, Waldron L, Wall M, Wang Q, Warren J, Warry GL, Wei X, West A, Whitehead SL, Whiteley MN, Wilkinson JE, Willey DL, Williams G, Williams L, Williamson A, Williamson H, Wilming L, Woodmansey RL, Wray PW, Yen J, Zhang J, Zhou J, Zoghbi H, Zorilla S, Buck D, Reinhardt R, Poustka A, Rosenthal A, Lehrach H, Meindl A, Minx PJ, Hillier LW, Willard HF, Wilson RK, Waterston RH, Rice CM, Vaudin M, Coulson A, Nelson DL, Weinstock G, Sulston JE, Durbin R, Hubbard T, Gibbs RA, Beck S, Rogers J, Bentley DR.
The DNA sequence of the human X chromosome.
Nature. 2005 Mar 17;434(7031):325-37.
PMID: 15772651 [PubMed - indexed for MEDLINE]

Basu J, Stromberg G, Compitello G, Willard HF, Van Bokkelen G.
Rapid creation of BAC-based human artificial chromosome vectors by transposition with synthetic alpha-satellite arrays.
Nucleic Acids Res. 2005 Jan 26;33(2):587-96. Print 2005.
PMID: 15673719 [PubMed - indexed for MEDLINE]

Chadwick BP, Willard HF.
Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosome.
Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17450-5. Epub 2004 Dec 1.
PMID: 15574503 [PubMed - indexed for MEDLINE]

Grimes BR, Babcock J, Rudd MK, Chadwick B, Willard HF.
Assembly and characterization of heterochromatin and euchromatin on human artificial chromosomes.
Genome Biol. 2004;5(11):R89. Epub 2004 Oct 27.
PMID: 15535865 [PubMed - indexed for MEDLINE]

Rudd MK, Willard HF.
Analysis of the centromeric regions of the human genome assembly.
Trends Genet. 2004 Nov;20(11):529-33.
PMID: 15475110 [PubMed - indexed for MEDLINE]

Chadwick BP, Willard HF.
Barring gene expression after XIST: maintaining facultative heterochromatin on the inactive X.
Semin Cell Dev Biol. 2003 Dec;14(6):359-67. Review.
PMID: 15015743 [PubMed - indexed for MEDLINE]

Simpson JL, de la Cruz F, Swerdloff RS, Samango-Sprouse C, Skakkebaek NE, Graham JM Jr, Hassold T, Aylstock M, Meyer-Bahlburg HF, Willard HF, Hall JG, Salameh W, Boone K, Staessen C, Geschwind D, Giedd J, Dobs AS, Rogol A, Brinton B, Paulsen CA.
Klinefelter syndrome: expanding the phenotype and identifying new research directions.
Genet Med. 2003 Nov-Dec;5(6):460-8.
PMID: 14614399 [PubMed - indexed for MEDLINE]

Rudd MK, Mays RW, Schwartz S, Willard HF.
Human artificial chromosomes with alpha satellite-based de novo centromeres show increased frequency of nondisjunction and anaphase lag.
Mol Cell Biol. 2003 Nov;23(21):7689-97.
PMID: 14560014 [PubMed - indexed for MEDLINE]

Percec I, Thorvaldsen JL, Plenge RM, Krapp CJ, Nadeau JH, Willard HF, Bartolomei MS.
An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse.
Genetics. 2003 Aug;164(4):1481-94.
PMID: 12930754 [PubMed - indexed for MEDLINE]

Chadwick BP, Willard HF.
Chromatin of the Barr body: histone and non-histone proteins associated with or excluded from the inactive X chromosome.
Hum Mol Genet. 2003 Sep 1;12(17):2167-78. Epub 2003 Jul 15.
PMID: 12915472 [PubMed - indexed for MEDLINE]

Willard HF.
Tales of the Y chromosome.
Nature. 2003 Jun 19;423(6942):810-1, 813. No abstract available.
PMID: 12815408 [PubMed - indexed for MEDLINE]

Williams RS, Willard HF, Snyderman R.
Personalized health planning.
Science. 2003 Apr 25;300(5619):549. No abstract available.
PMID: 12714710 [PubMed - indexed for MEDLINE]

Chadwick BP, Willard HF.
SETting the stage. Eed-Enx1 leaves an epigenetic signature on the inactive X chromosome.
Dev Cell. 2003 Apr;4(4):445-7. Review.
PMID: 12689584 [PubMed - indexed for MEDLINE]

Chadwick BP, Willard HF.
Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome.
J Cell Biol. 2002 Jun 24;157(7):1113-23. Epub 2002 Jun 24.
PMID: 12082075 [PubMed - indexed for MEDLINE]

Hall LL, Byron M, Sakai K, Carrel L, Willard HF, Lawrence JB.
An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells.
Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8677-82. Epub 2002 Jun 18.
PMID: 12072569 [PubMed - indexed for MEDLINE]

Plenge RM, Stevenson RA, Lubs HA, Schwartz CE, Willard HF.
Skewed X-chromosome inactivation is a common feature of X-linked mental retardation disorders.
Am J Hum Genet. 2002 Jul;71(1):168-73. Epub 2002 May 30.
PMID: 12068376 [PubMed - indexed for MEDLINE]

Grimes BR, Rhoades AA, Willard HF.
Alpha-satellite DNA and vector composition influence rates of human artificial chromosome formation.
Mol Ther. 2002 Jun;5(6):798-805.
PMID: 12027565 [PubMed - indexed for MEDLINE]

Percec I, Plenge RM, Nadeau JH, Bartolomei MS, Willard HF.
Autosomal dominant mutations affecting X inactivation choice in the mouse.
Science. 2002 May 10;296(5570):1136-9.
PMID: 12004136 [PubMed - indexed for MEDLINE]

Willard HF.
2001 ASHG Presidential Address. On black boxes and storytellers: lessons learned in human genetics.
Am J Hum Genet. 2002 Feb;70(2):285-96. Epub 2002 Jan 4. No abstract available.
PMID: 11781874 [PubMed - indexed for MEDLINE]

 

 

Contact Information

Huntington F. Willard
Phone: 919-668-4477
CIEMAS 2379
hunt.willard@duke.edu

Lynne Skinner
Assistant to Dr. Willard
Phone: 919-668-4477
CIEMAS 2376
lynne.skinner@duke.edu

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