Joseph R. Nevins, PhD
Publications (2006-2008)
1. Bild, A. H., Yao, G., Chang, J. T., Wang, Q., Potti, A., Chasse, D., Joshi, M-B., Harpole, D., Lancaster, J.M., Berchuck, A., Olson, Jr., J.A., Marks, J.R., Dressman, H. K., West, M., and Nevins, J. R. (2006). Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439, 353-357.
2. West, M., Ginsburg, G. S., Huang, A. T., and Nevins, J. R. (2006). Embracing the complexity of genomic data for personalized medicine. Genome Res., 16, 559-566.
3. Potti, A., Bild, A., Dressman, H., Lewis, D., Nevins, J. R., and Ortel, T.L. (2006). Gene expression patterns predict phenotypes of immune-mediated thrombosis. Blood 107, 1391-1396.
4. Dressman, H. K., Hans, C., Bild, A., Marks, J., Olson, J. A., Rosen, E., Marcom, P. K., Liotcheva, V., Jones, E., Vujaskovic, Z., Dewhirst, M. W., West, M., Nevins, J. R., and Blackwell, K. L. (2006). Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy. Clin. Cancer Res. 12, 819-826.
5. Hallstrom, T. C. and Nevins, J. R. (2006). Jab1 is a specificity factor for E2F1-induced apoptosis. Genes & Dev. 20, 613-623.
6. Kong, L.-J., Meloni, A., and Nevins, J. R. (2006). The Rb-related p130 protein controls telomere lengthening through an interaction with Rad50 interacting protein RINT-1. Mol Cell 22, 63-71.
7. Lancaster, J. M., Dressman, H. K., Pittman, J. L., Sayer, R. A., Martino, M. A., Cragun, J. M., Henriott, A. H., Gray, J., Sutphen, R., Elahi, A., Whitaker, R. S., West, M., Marks, J. R., Nevins, J. R., and Berchuck, A. (2006). Identification of genes associated with ovarian cancer metastasis using microarray expression analysis. Int. J. Gyn. Can. 16, 1733-1745.
8. Potti, A., Mukherjee, S., Prince, R., Dressman, H. K., Bild, A., Koontz, J., Kratzke, R., Watson, M., Kelley, M., Ginsburg, G., Harpole, D., and Nevins, J. R. (2006). A genomic strategy to refine prognosis in non-small cell lung carcinoma. N. Engl. J. Med. 355, 570-580.
9. Bild, A., Potti, A., and Nevins, J. R. (2006). Focusing on pathways to address complex biological and clinical phenotypes. Nat. Rev. Cancer 6, 735-741.
10. Potti, A., Dressman, H. K., Bild, A., Riedel, R. F., Chan, G., Sayer, R., Cragun, J., Cottrill, H., Gray, J., Marks, J., Kelley, M., Berchuck, A., Petersen, R., Harpole, D., Ginsburg, G. S., Febbo, P., Lancaster, J. M., and Nevins, J. R. (2006). A genomic strategy to guide the use of chemotherapeutic drugs in solid tumors. Nat. Med. 12, 1294-1300.
11. Chang, J. T. and Nevins, J. R. (2006). GATHER – a systems approach to interpreting genomic signatures. Bioinformatics 22, 2926-2933.
12. Cheng, S.-H., Horng, C.-F., West, M., Huang, E., Pittman, J., Tsou, M.-H., Dressman, H., Chen, C.-M., Tsai, S. Y., Jian, J. J., Liu, M.-C., Nevins, J. R., and Huang, A. T. (2006). Genomic prediction of loco-regional recurrence following mastectomy in breast cancer. J. Clin. Oncol. 24, 4594-4602.
13. Nevins, J. R. (2007). Cell transformation by viruses. In Fields Virology, 5th edition (D.N. Knipe and P.M. Howley, ed), Lippincott-Raven Press, Philadelphia, PA, pp 209-248.
14. Kong, L.-J., Chang, J., and Nevins, J. R. (2007). Compensation and specificity of function within the E2F family. Oncogene 26, 321-327.
15. Dressman, H. K., Chan, G., Zhai, J., Bild, A., Cragun, J., Sayer, R., Clarke, J., Whitaker, R., Gray, J., Marks, J., Ginsburg, G., Potti, A., West, Berchuck, A., Nevins, J.R., and Lancaster, J. M. (2007). A genomic strategy to personalized treatment of patients with advanced-stage ovarian cancer. J. Clin. Oncol. 25, 517-525.
16. Dressman, H. K., Muramoto, G. G., Chao, N. J., Ginsburg, G. S., Nevins, J. R., and Chute, J. P. (2007). Gene expression signatures that predict levels of radiation exposure. PLOS Medicine 4, e106.
17. Nevins, J. R. and Potti, A. (2007). Mining gene expression profiles: expression signatures as cancer phenotypes. Nat. Rev. Genet. 8, 601-609.
18. Giangrande, P. H., Zhang, J. X., Tanner, A., Eckhart, A. D., Rempel, R. E., Andrechek, E. R., Layzer, J. M., Keys, J. R., Hagen, P. O., Nevins, J. R., Koch, W. J., and Sullenger, B. A. (2007). Distinct roles for E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia. Proc. Nat’l. Acad. Sci. 104, 12988-12993.
19. Garman, K. S., Nevins, J. R., and Potti, A. (2007). Genomic strategies for personalized cancer therapy. Hum. Mol. Genet. 16, R226-232.
20. Bonnefoi, H., Potti, A., Piccart, M., Mauriac, L., Campone, M., Tubiana-Hulin, M., Petit, T., Rouanet, P., Jassem, J., Blot, E., Becette, V., Farmer, P., Andre, S., Cameron, D., Bergh, J., Delorenzi, M., Nevins, J. R., and Iggo, R. D. (2007). Validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00-01 clinical trial. Lancet Oncol. 8, 1071-1078.
21. Hsu, D. S., Balakumaran, B. S., Acharya, C. R., Vlahovic, V., Walters, K. S., Garman, K., Anders, C., Riedel, R. F., Lancaster, J., Harpole, D., Dressman, H. K., Febbo, P. G., Nevins, J. R., and Potti, A. (2007). Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer. J. Clin. Oncol. 25, 4350-4357.
22. Huang, W., Nevins, J. R., and Ohler, U. (2007). Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessing their impact on alignment tools. Genome Biol. 8, R225.
23. Nevins, J. R. (2007). New breast cancer genes – discovery at the intersection of complex datasets. Cancer Cell 12, 497-499.
24. Hallstrom, T. C., Mori, S., and Nevins, J. R. (2008). An E2F1-dependent gene expression program that determines the balance between proliferation and cell death. Cancer Cell 13, 11-22.
25. Potti, A. and Nevins, J. R. (2008). Utilization of genomic signatures to direct use of primary chemotherapy. Curr. Opin. Genet. Develop., in press.
26. Potti, A. and Nevins, J. R. (2008). Towards the individualization of lung cancer therapy. Cancer, in press.
27. Marcom, P. K., Anders, C.K., Ginsburg, G.S., Nevins, J. R., and Potti, A. (2008). Utilization of genomic signatures for personalized treatment of breast cancer. In: “Pharmacogenetics of Breast Cancer”, B. Leyland-Jones, ed., MacMillan Publishing Solutions, Chapter 6, pages 73-89.
28. Anders, C. K., Acharya, C. R., Hsu, D. S., Broadwater, G., Garman, K., Foekens, J. A., Zhang, Y., Wang, Y., Marcom, K., Marks, J. R., Mukherjee, S., Nevins, J. R., Blackwell, K. L., and Potti, A. (2008). Age-specific differences in oncogenic pathway deregulation seen in human breast tumors. PLoS ONE 3, e1373.
29. Yao, G., Lee, T. J., Mori, S., Nevins, J. R., and You, L. (2008). A bistable Myc-Rb-E2F switch: a model for the restriction point. Nat. Cell Biol. 10, 476-482.
30. Carvalho, C., Chang, J., Lucas, J., Nevins, J. R., Wang, Q., and West, M. (2008). High dimensional sparse factor modeling: applications in gene expression genomics. J. Am. Stat. Assoc., in press.
31. Anders, C. K., Hsu, D. S., Broadwater, G., Acharya, C. R., Foekens, J. A., Zhang, Y., Wang, Y., Marcom, K., Marks, J. R., Nevins, J. R., Potti, A., and Blackwell, K. L. (2008). Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J. Clin. Oncol., in press.
32. Leung, J., Ehmann, G. L., Giangrande, P. H., and Nevins, J. R. (2008). Myc is required for E2F-dependent G1/S control: a mechanism to link the preparation for cell growth with entry into the cell cycle. Oncogene, in press.
33. Lee, T. Yao, G., Nevins, J. R., and You, L. (2008). Sensing and integration of Erk and PI3K signals by Myc. PLoS Comp. Biol., in press.
34. Meadows, S. K., Dressman, H. K., Muramoto, G. G., Himburg, H., Salter, A., Wei, Z. Z., Ginsburg, G., Chao, N. J., Nevins, J. R., and Chute, J. P. (2008). Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS ONE 3, e1912-e1912.
35. Acharya, C. R., Hsu, D. S., Anders, C. K., Anguiano, A., Salter, K. H., Walters, K. S., Redman, R. C., Tuchman, S. A., Moylan, C. A., Mukherjee, S., Barry, W. T., Dressman, H. K., Ginsburg, G. S., Marcom, K. P., Garman, K. S., Lyman, G. H., Nevins, J. R., and Potti, A. (2008). Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer. JAMA 299, 1574-1587.
36. Salter, K. H., Acharya, C. R., Walters, K. S., Redman, R., Anguiano, A., Garman, K. S., Anders, C. K., Mukherjee, S., Dressman H. K., Barry, W. T., Marcom, K. P., Olson, J., Nevins, J. R., and Potti, A. (2008). An integrated approach to the prediction of chemotherapeutic response in patients with breast cancer. PLoS ONE 3, e1908.
37. Andrecheck, E. R., Mori, S., Rempel, R. E., Chang, J. T., and Nevins, J. R. (2008). Patterns of cell signaling pathway activation that characterize mammary development. Development, in press.
38. Hallstrom, T. and Nevins, J. R. (2008). Balancing the decision of cell proliferation and cell fate. Cell Cycle, in press.
39. Mori, S., Rempel, R. E., Chang, J. T., Yao, G., Lagoo, A. S., Potti, A., and Nevins, J. R. (2008). Utilization of pathway signatures to reveal distinct types of B lymphoma in the E-myc model and human DLBCL. Cancer Res., in press.
Contact Information
Joseph R. Nevins
Phone: 919-684-2746
2121 CIEMAS
j.nevins@duke.edu
Kaye Culler
Administrative Coordinator
Phone: 919-684-2746
2121 CIEMAS
kaye.culler@duke.edu