Joseph R. Nevins, PhD
Director, IGSP Center for Applied Genomics & Technology
"This is an exciting time where genomics offers the promise of a deeper understanding of biology while at the same time improving the practice of medicine."Dr. Joseph Nevins is Barbara Levine Professor of Breast Cancer Genomics and Director of the IGSP's Center for Applied Genomics & Technology. His research focuses on the gene regulatory events associated with the control of cellular proliferation and cell fate, including the dysregulation that contributes to oncogenesis. This work has specifically focused on the retinoblastoma tumor suppressor (Rb) and the role of this protein in controlling the E2F transcription factor activities. Additionally, work in the Nevins lab has focused on the interplay of cellular signaling pathways that in combination control cell proliferation including the role of Ras, Myc, and other activities. Finally, a major component of the effort in the lab focuses on the use of genome-scale measures of gene expression, employing DNA microarrays, to identify expression profiles that characterize oncogenic pathways and that define tumor phenotypes of importance in determining clinical outcomes.
Contact Information
Joseph R. Nevins
Phone: 919-684-2746
2121 CIEMAS
j.nevins@duke.edu
Kaye Culler
Administrative Coordinator
Phone: 919-684-2746
2121 CIEMAS
kaye.culler@duke.edu