Phillip Febbo, MD
Publications
Potti A, Dressman HK, Bild A, Riedel RF, Chan G, Sayer R, Cragun J, Cottrill H, Kelley MJ, Petersen R, Harpole D, Marks J, Berchuck A, Ginsburg GS, Febbo P, Lancaster J, Nevins JR.
Genomic signatures to guide the use of chemotherapeutics.
Nat Med. 2006 Nov;12(11):1294-300. Epub 2006 Oct 22.
PMID: 17057710 [PubMed - indexed for MEDLINE]
Priolo C, Tang D, Brahamandan M, Benassi B, Sicinska E, Ogino S, Farsetti A, Porrello A, Finn S, Zimmermann J, Febbo P, Loda M.
The Isopeptidase USP2a Protects Human Prostate Cancer from Apoptosis.
Cancer Res. 2006 Sep 1;66(17):8625-32.
PMID: 16951176 [PubMed - in process]
Edelman E, Porrello A, Guinney J, Balakumaran B, Bild A, Febbo PG, Mukherjee S.
Analysis of sample set enrichment scores: assaying the enrichment of sets of genes for individual samples in genome-wide expression profiles.
Bioinformatics. 2006 Jul 15;22(14):e108-16.
PMID: 16873460 [PubMed - indexed for MEDLINE]
Balakumaran BS, Febbo PG.
New insights into prostate cancer biology.
Hematol Oncol Clin North Am. 2006 Aug;20(4):773-96. Review.
PMID: 16861114 [PubMed - indexed for MEDLINE]
Febbo PG, Kantoff PW.
Noise and bias in microarray analysis of tumor specimens.
J Clin Oncol. 2006 Aug 10;24(23):3719-21. Epub 2006 Jul 5. No abstract available.
PMID: 16822841 [PubMed - indexed for MEDLINE]
Riedel RF, Febbo PG.
Epidermal growth factor receptor mutations predict sensitivity to gefitinib in patients with non-small-cell lung cancer.
Future Oncol. 2005 Aug;1(4):461-6. Review.
PMID: 16556022 [PubMed - indexed for MEDLINE]
Bismar TA, Demichelis F, Riva A, Kim R, Varambally S, He L, Kutok J, Aster JC, Tang J, Kuefer R, Hofer MD, Febbo PG, Chinnaiyan AM, Rubin MA.
Defining aggressive prostate cancer using a 12-gene model.
Neoplasia. 2006 Jan;8(1):59-68.
PMID: 16533427 [PubMed - indexed for MEDLINE]
Stanbrough M, Bubley GJ, Ross K, Golub TR, Rubin MA, Penning TM, Febbo PG, Balk SP.
Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer.
Cancer Res. 2006 Mar 1;66(5):2815-25.
PMID: 16510604 [PubMed - indexed for MEDLINE]
Febbo PG, Thorner A, Rubin MA, Loda M, Kantoff PW, Oh WK, Golub T, George D.
Application of oligonucleotide microarrays to assess the biological effects of neoadjuvant imatinib mesylate treatment for localized prostate cancer.
Clin Cancer Res. 2006 Jan 1;12(1):152-8.
PMID: 16397037 [PubMed - indexed for MEDLINE]
Bild A, Febbo PG.
Application of a priori established gene sets to discover biologically important differential expression in microarray data.
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15278-9. Epub 2005 Oct 17. No abstract available.
PMID: 16230612 [PubMed - indexed for MEDLINE]
Febbo PG, Richie JP, George DJ, Loda M, Manola J, Shankar S, Barnes AS, Tempany C, Catalona W, Kantoff PW, Oh WK.
Neoadjuvant docetaxel before radical prostatectomy in patients with high-risk localized prostate cancer.
Clin Cancer Res. 2005 Jul 15;11(14):5233-40.
PMID: 16033841 [PubMed - indexed for MEDLINE]
Alvarez JV, Febbo PG, Ramaswamy S, Loda M, Richardson A, Frank DA.
Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors.
Cancer Res. 2005 Jun 15;65(12):5054-62.
PMID: 15958548 [PubMed - indexed for MEDLINE]
Berchuck A, Iversen ES, Lancaster JM, Pittman J, Luo J, Lee P, Murphy S, Dressman HK, Febbo PG, West M, Nevins JR, Marks JR.
Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers.
Clin Cancer Res. 2005 May 15;11(10):3686-96.
PMID: 15897565 [PubMed - indexed for MEDLINE]
Febbo PG, Lowenberg M, Thorner AR, Brown M, Loda M, Golub TR.
Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer.
J Urol. 2005 May;173(5):1772-7.
PMID: 15821585 [PubMed - indexed for MEDLINE]
Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA, Akashi K, Korsmeyer SJ.
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.
EMBO J. 2005 Jan 26;24(2):368-81. Epub 2005 Jan 6.
PMID: 15635450 [PubMed - indexed for MEDLINE]
Berger R, Febbo PG, Majumder PK, Zhao JJ, Mukherjee S, Signoretti S, Campbell KT, Sellers WR, Roberts TM, Loda M, Golub TR, Hahn WC.
Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.
Cancer Res. 2004 Dec 15;64(24):8867-75.
PMID: 15604246 [PubMed - indexed for MEDLINE]
Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, Manola J, Brugarolas J, McDonnell TJ, Golub TR, Loda M, Lane HA, Sellers WR.
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.
Nat Med. 2004 Jun;10(6):594-601. Epub 2004 May 23.
PMID: 15156201 [PubMed - indexed for MEDLINE]
Paris PL, Andaya A, Fridlyand J, Jain AN, Weinberg V, Kowbel D, Brebner JH, Simko J, Watson JE, Volik S, Albertson DG, Pinkel D, Alers JC, van der Kwast TH, Vissers KJ, Schroder FH, Wildhagen MF, Febbo PG, Chinnaiyan AM, Pienta KJ, Carroll PR, Rubin MA, Collins C, van Dekken H.
Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors.
Hum Mol Genet. 2004 Jul 1;13(13):1303-13. Epub 2004 May 11.
PMID: 15138198 [PubMed - indexed for MEDLINE]
Febbo PG, Sellers WR.
Use of expression analysis to predict outcome after radical prostatectomy.
J Urol. 2003 Dec;170(6 Pt 2):S11-9; discussion S19-20.
PMID: 14610405 [PubMed - indexed for MEDLINE]
Lieberfarb ME, Lin M, Lechpammer M, Li C, Tanenbaum DM, Febbo PG, Wright RL, Shim J, Kantoff PW, Loda M, Meyerson M, Sellers WR.
Genome-wide loss of heterozygosity analysis from laser capture microdissected prostate cancer using single nucleotide polymorphic allele (SNP) arrays and a novel bioinformatics platform dChipSNP.
Cancer Res. 2003 Aug 15;63(16):4781-5.
PMID: 12941794 [PubMed - indexed for MEDLINE]
Rossi S, Graner E, Febbo P, Weinstein L, Bhattacharya N, Onody T, Bubley G, Balk S, Loda M.
Fatty acid synthase expression defines distinct molecular signatures in prostate cancer.
Mol Cancer Res. 2003 Aug;1(10):707-15.
PMID: 12939396 [PubMed - indexed for MEDLINE]
Majumder PK, Yeh JJ, George DJ, Febbo PG, Kum J, Xue Q, Bikoff R, Ma H, Kantoff PW, Golub TR, Loda M, Sellers WR.
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7841-6. Epub 2003 Jun 10.
PMID: 12799464 [PubMed - indexed for MEDLINE]
Contact Information
Phillip Febbo
Phone: 919-668-4774
2175 CIEMAS
phil.febbo@duke.edu